منابع مشابه
Noncoding RNAs and Gene Silencing
Noncoding RNA has long been proposed to control gene expression via sequence-specific interactions with regulatory regions. Here, we review the role of noncoding RNA in heterochromatic silencing and in the silencing of transposable elements (TEs), unpaired DNA in meiosis, and developmentally excised DNA. The role of cotranscriptional processing by RNA interference and by other mechanisms is dis...
متن کاملnoncoding rnas and cancer
the eukaryotic complexity involves the expression and regulation of genes via rna-dna, rna-rna, dna-protein and rna-protein interactions. recently, the role of rna molecules in the regulation of genes in higher organisms has become more evident, especially with the discovery that about 97% of the transcriptional output in higher organisms are represented as noncoding rnas: rrna, snornas, trna, ...
متن کاملSilencing long noncoding RNAs with genome-editing tools.
Long noncoding RNAs (lncRNAs) are a functional and structural diverse class of cellular transcripts that comprise the largest fraction of the human transcriptome. However, detailed functional analysis lags behind their rapid discovery. This might be partially due to the lack of loss-of-function approaches that efficiently reduce the expression of these transcripts. Here, I describe a method tha...
متن کاملSpecific gene silencing by artificial trans-encoded small noncoding RNAs in bacteria
The authors of the paper ‘Specific gene silencing by artificial trans-encoded small noncoding RNAs in bacteria’ (Nucleic Acids Res. May 27, 2009. doi:10.1093/nar/gkp447, PMID: 19474345 [Epub ahead of print]) wish it to be known that they have found several site mutations in the sequences of CY6 and N-CY1, which cause some changes in the secondary structure of the two atsRNAs. The conclusions dr...
متن کاملNoncoding RNAs
Recent years have witnessed many remarkable discoveries in the life sciences that have led to major paradigm shifts. An example is the emerging appreciation of the critical role of noncoding RNAs in a broad range of physiological and pathological processes. One such class of noncoding RNAs, the microRNAs (miRNAs), controls intricate networks of gene expression via post-transcriptional mechanism...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2007
ISSN: 0092-8674
DOI: 10.1016/j.cell.2007.02.016